The cell-based bioassay and potency development and operation require the correct partner because they are among the trickiest techniques needed in the drug development process. In vitro bioassays are essential for determining potency but they can also evaluate biological activity between the mAb, its target, and Fc effector activities in a way that is truly physiologically relevant.
Our extensive selection of cell-based bioassay platform techniques that are available to be tailored for your biobetter molecule includes:
Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) Assays and Custom Potency Assays
• Assays for antibody-dependent cellular phagocytosis
• CDC Assays for Complement-Dependent Cytotoxicity
• Tests on immune cells
We offer a detection solution through the Mechanism of Action, from early candidate selection and product characterization to production (MOA). Fluorescence, luminescence, and fluorescence resonance energy transfer (FRET), among others, are versatile endpoints that can be used in our testing technique to measure MOA in a larger range of contexts, such as:
• Cell Proliferation
• Neutralize
• Cytokine release
• Cell signal modulation
• Regulation of inflammatory response (immune cell function and supplement)
• Receptor activation
• Cell Death (apoptosis / necrosis)