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Asialoglycoprotein Receptor

  • Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis on mucosal surfaces and play a role in immune protection. IgA functions mainly through interaction with multiple receptors, including the asialoglycoprotein receptor (ASGPR). ASGPR is a type C carbohydrate-binding lectin that mediates the clearance of various defective plasma glycoprotein molecules from the body. These receptors also identify and bind to pathogen membrane glycoproteins to efficiently clear them from circulation by receptor-mediated endocytosis and play a pivotal role in preventing hepatocyte infections, inflammation, and cancer.