Recent Entries

  • Half-Life Extension Chemical Modifications

    Half-life extension chemical modification of peptides and proteins has become an essential route to enhance the PK profile of biopharmaceuticals. Herein we provide an overview of some important chemical modifications to extend the half-life of biopharmaceuticals, which are alternatives to PEGyl...
  • Drug Development Targets in Ribosome

    Research into bacterial ribosomes and the development of ribosome-targeting antibiotics have been important in the fight against pathogenic bacteria and have made outstanding contributions to human health. However, serious problems have developed, including bacterial drug resistance, and the toxicit...
  • Ribavirin for SARS-CoV-2

    One of the fastest and most effective methods of drug discovery is to test whether existing antiviral drugs can effectively treat emerging viral infections. Researchers are evaluating countermeasures for SARS-CoV-2 using SARS and MERS as prototypes. Several antiviral drugs, including ribavirin, inte...
  • Single Cell RNA-Seq Analysis

    The authors used single-cell RNA sequencing (scRNA-seq) to identify a noncoding RNA (ncRNA) called LINC00968 that mediates resistance to sorafenib treatment in hepatocellular carcinoma (HCC) cells. Sorafenib is a drug that inhibits multiple kinases involved in cancer growth and survival, b...
  • Ribosome and Breast Cancer

    Current evidence suggests that regulation of ribosome biogenesis is the primary mechanism by which many drugs exert their cytotoxic activity against cancer cells. It is worth noting that ribosome and breast cancer are inextricably linked. BC, the most frequent malignancy in women, has beco...