Tadalista, which contains tadalafil, can become ineffective in several situations. Its effectiveness may decline if it is not taken correctly, such as consuming it with heavy, fatty meals that delay absorption. Over time, some men may experience reduced results if underlying health conditions like diabetes, hypertension, or hormonal imbalances worsen, since these affect erectile function regardless of medication. Ineffectiveness may also occur due to drug tolerance, though true tolerance to Tadalista is uncommon. Additionally, interactions with alcohol, smoking, or certain medications (like nitrates or alpha-blockers) can interfere with its action. Psychological issues such as stress, anxiety, or relationship difficulties may also make Tadalista seem less effective, even when it is working physiologically. Consulting a doctor is important if Tadalista stops producing the desired results.