Amount of Triglyceride in the Blood
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September 10, 2018 2:18 AM EDTSirolimus belongs to a group of medicines called immunosuppressants. It helps to control the body's immune system after received an organ transplant. It is used to prevent the body from rejecting the transplanted kidney.
Mechanism of action:
This drug inhibits T lymphocyte activation and proliferation Ryan Zimmerman Nationals Jersey , which occurs in response to antigenic and cytokine stimulation; however, its mechanism is distinct from that of other immunosuppressants. It also inhibits antibody production in cells. This product binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus: FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the phase progression of the cell cycle.
Indications:
This drug is indicated for the prophylaxis of organ rejection in adult patients at low to moderate immunological risk receiving a renal transplant. It is recommended that it can be used initially in combination with ciclosporin microemulsion and corticosteroids for 2 to 3 months. This drug may be continued as maintenance therapy with corticosteroids only if ciclosporin microemulsion can be progressively discontinued .
Interactions:
Some medicines may interfere with each other. These include:
- cyclosporin used to prevent transplant rejection
- antibiotics such as rifampicin, clarithromycin, erythromycin and rifabutin
- antifungal medicines such as ketoconazole, clotrimazole, fluconazole and itraconazole
- medicines for high blood pressure or heart problems such as diltiazem, nicardipine and verapamil
- epilepsy medicines such as carbamazepine, phenobarbitone and phenytoin
- medicines for stomach ulcer or reflux such as cimetidine and cisapride
- medicines to prevent nausea and vomiting such as metoclopramide
- danazol which is used to treat endometriosis
- bromocriptine which is used to treat Parkinson's disease
- protease inhibitors such as ritonavir and indinavir, which are used to treat HIVAIDS
- St. John's wort.
- These medicines may be affected by Sirolimus, or may affect how well it works.
Precautions:
This drug is not recommended for use during pregnancy because it may cause birth defects. Therefore, it is very important that an effective form of birth control be used before starting sirolimus therapy, during this therapy, and for 12 weeks after this therapy has stopped. However, because this medicine may cause serious side effects, breast-feeding is not recommended while you are receiving it.
Side effects:
- High Blood Pressure, Acne
- Kidney Disease, Rash, Fever
- Urinary Tract Infection
- Fluid Retention in the Legs, Feet, Arms or Hands
- High Cholesterol, Stomach Cramp
- Low Amount of Potassium in the Blood
- Reduction in the Body's Resistance to Infection
- Anemia, Joint pain
- Decreased Blood Platelets
- Incomplete or Infrequent Bowel Movements
- Visible Water Retention, Head pain
- Feel Like Throwing Up, Diarrhea
- High Amount of Triglyceride in the Blood
Storage:
- Keep this tablet in their blister pack until it is time to take them.
- If you take the tablets out of their blister pack they may not last as well.
- Keep this drug in a cool, dry place where the temperature stays below 250C.
- Do not store this tablets or any other medicine in the bathroom or near a sink.
- Heat and dampness can destroy some medicines. Keep this medicine where children cannot reach it.
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