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Gemini Smith
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Gemini Smith wrote a new blog entry: The COVID-19 pandemic, which emerged at the end of 2019, may have receded from public consciousness, but its impact continues to reverberate. Over the past three years, countries worldwide have grappled with multiple waves of widespread infection. Althoug...
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Gemini Smith wrote a new blog entry: The hallmark of rheumatoid arthritis (RA) is erosive arthritis, an autoimmune disease that ultimately results in joint deformities and functional loss. It can also be complicated by pulmonary disease, cardiovascular disease, malignant tumors, and depressi...
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Gemini Smith wrote a new blog entry: Pharmaceutical corporations and academic institutions have invested significant time, money, and effort in recent years to increase the accuracy and applicability of in vitro screening technology, which measures the biological activity and physicochemical...
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Gemini Smith wrote a new blog entry: The half-life assay by bleach-chase is applicable to fluorescently tagged proteins and can be applied to multiple proteins and time points in living cells. Furthermore, this method is suitable for high-throughput protein half-life determination, making ...
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Gemini Smith wrote a new blog entry: mRNAs have varying translation efficiency, which can alter rapidly during adaptation to various environmental conditions such as cellular stressors and microbial infections. Polysome profiling, or the examination of mRNAs associated with polysomes, has be...
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Gemini Smith wrote a new blog entry: Similar to other enveloped RNA viruses, SARS-CoV-2 has a trimeric spike
protein on its viral envelope. Since the trimeric S protein of SARS-CoV-2 is responsible for binding to the host cell surface receptor ACE2 and mediating subsequent viral entry, t... -
Gemini Smith wrote a new blog entry: Microfluidics is also called laboratory on a chip (LOC). Since their development, microfluidic technologies have revolutionized the way for experimental biology and biomedical research, along with significant improvements in the fields of chemical synthes...
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Gemini Smith wrote a new blog entry: As an important molecule involved in various physiological processes in cells, protein is typically generated or released in multiple, transient pulses and in low abundance. Because genomic analysis lacks efficient PCR-like amplification techniques, singl...
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Gemini Smith wrote a new blog entry: Antibody therapy has become an important part of the treatment of malignant diseases. Antibodies can block tumor growth factors or their receptors, activate immune attacks on tumors, and be used to deliver payloads such as radioisotopes, cytotoxic drugs...
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Gemini Smith wrote a new blog entry: Microfluidic health monitoring devices provide revolutionary tools for biological diagnostics and industrial applications. Miniaturized microfluidic sensors integrate key steps such as sample collection, separation, and detection into a single chip a...
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Gemini Smith wrote a new blog entry: Exosomes have specialized functions and play a key role in different physiological processes and pathological conditions. Consequently, exosomes have attracted increasing attention in their clinical applications for prognosis, diagnosis, drug delivery, an...
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Gemini Smith wrote a new blog entry: Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis on mucosal surfaces and play a role in immune protection. IgA functions mainly through interaction with multiple rec...
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Gemini Smith wrote a new blog entry: We have developed an innovative and proprietary platform for next-generation CAR-engineered cell therapies (CAR macrophage therapies) with great therapeutic potential for solid tumor (see Fig.3). Our unique and proprietary CAR-MA platform is utilized to m...
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Gemini Smith wrote a new blog entry: Half-life extension chemical modification of peptides and proteins has become an essential route to enhance the PK profile of biopharmaceuticals. Herein we provide an overview of some important chemical modifications to extend the half-life of biopha...
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Gemini Smith wrote a new blog entry: Research into bacterial ribosomes and the development of ribosome-targeting antibiotics have been important in the fight against pathogenic bacteria and have made outstanding contributions to human health. However, serious problems have developed, includi...