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What is the resolution of Stereo-Seq?
Stereo-Seq (Spatial Enhanced Resolution Omics-Sequencing) is an advanced spatial transcriptomics technology known for its ultra-high resolution and wide field of view. But what is the resolution of Stereo-Seq? This innovative method achieves subcellular resolution, enabling the precise localization of gene expression at the nanoscale level. The technology utilizes DNA nanoballs (DNBs) on a high-density chip, providing a spatial resolution as fine as 500 nanometers (nm).
Compared to traditional spatial transcriptomics techniques, Stereo-Seq offers unparalleled spatial precision, making it ideal for single-cell and even subcellular transcriptomic mapping. Its resolution enables researchers to study tissue architecture in extreme detail, revealing intricate cellular interactions and molecular landscapes.
The high resolution of Stereo-Seq is particularly beneficial for applications in neuroscience, cancer research, and developmental biology, where understanding cellular microenvironments is crucial. By offering nanoscale resolution combined with a large field of view, Stereo-Seq provides an unprecedented ability to analyze complex biological systems with clarity.
In summary, the resolution of Stereo-Seq can reach 500 nm, making it one of the most advanced spatial transcriptomics technologies available today. This level of detail allows scientists to explore gene expression patterns at an unmatched depth, revolutionizing spatial biology research.