Medical application of RNAi

• Posted by Samantha James June 23, 2021 Filed in Arts & Culture 380 views
  click to rate

  

  Treatment of viral diseases

  Researchers at the University of California, Los Angeles and California Institute of Technology have developed the use of RNAi technology to prevent HIV from entering human cells. The research team designed and synthesized the lenti virus vector to introduce siRNA to stimulate RNAi to inhibit the entry of coreceptor-CCR5 of HⅣ-1 into human peripheral T lymphocytes without affecting the other coreceptor-CCR4 of HⅣ-1. The lenti viral vector guides siRNA into the cell to generate an immune response, thereby greatly increasing the feasibility of treating HIV-1 and other viral infectious diseases. RNAi can also be applied to other viral infections such as polio virus. siRNA has been proven to mediate the intercellular antiviral immunity of human cells. Pretreatment of Magi cells with siRNA can enhance the resistance to viruses. RNAi has also received attention in the prevention and treatment of severe acute respiratory syndrome (SARS) that is distributed or endemic in about 30 countries and regions around the world. siRNA can effectively inhibit virus replication in the early stage of infection. Viral infection can be blocked by siRNA targeting viral genes and related host genes. These results suggest that RNAi can be competent for gene therapy of many viruses, and RNAi will become an effective Antiviral treatment. This is of great significance for the prevention and treatment of many serious animal infectious diseases.

  Treatment of hereditary diseases

  Carthew RW of Northwestern University in the United States and Ishizuka A of the Institute of Genetics of Japan and others found that RNAi is closely related to Fragile X Syndrome (a chromosomal disease related to FMR-1 gene abnormality that leads to mental retardation), revealing the relationship with RNAi Defects in related mechanisms may lead to the pathological mechanism of human diseases. RNAi treatment of genetic diseases has become another hot spot in RNAi research nowadays.

   

  Oncological treatment

  Tumors are the result of gene network regulation by the interaction of multiple genes. The blockade of a single oncogene induced by traditional techniques cannot completely inhibit or reverse the growth of tumors, while RNAi can make use of the homology of multiple genes in the same gene family With the characteristic of highly conserved sequence, the dsRNA molecule designed for this segment sequence can be injected with only one type of dsRNA to produce the performance of multiple genes being eliminated at the same time, or multiple dsRNAs can be injected at the same time to make multiple sequences unrelated. The genes of are eliminated at the same time. Maen et al. used RNAi technology to successfully block the function of Sp1, an abnormally expressed nuclear transcription factor gene related to cell proliferation and differentiation in MCF7 breast cancer cells. Although chemotherapy can effectively destroy tumor cells, it cannot effectively target tumor cells. Therefore, many normal cells die during the treatment process. Targeting tumor cells is also an important development direction for tumor therapy based on RNA interference. There have been many RNA interferences targeting different genes that have effectively inhibited the growth of tumor cells in vivo and in vitro. The genes for these purposes include: B c l-2, survivin, EGFR, VEGF, and so on. RNA interference replaces traditional antisense nucleic acid for post-transcriptional gene silencing, which can efficiently and specifically inhibit the target gene. Compared with traditional methods, RNA interference technology is simpler in design, quick in action, and effective. Its technical advantage is that it can design individualized treatment plans according to different conditions.

   

  About us

  BOC RNA is a sub-brand of BOC Sciences, which mainly focuses on RNA technology and its broad prospects in disease treatment.

  We provide comprehensive RNA related products and services, including siRNA design, synthesis, analysis, coupling, and delivery and mRNA vaccines, covering all development processes of RNA drugs.

  We will make every effort to help simplify and accelerate your drug discovery and disease treatment research efforts.