CD BioGlyco, a leading independent biotechnology company that is committed to discovering, developing, manufacturing and providing innovative glycobiology-related high quality products and services, recently developed a structure analysis platform with multiple world-leading technologies to help customers comprehensively progress in glycoprotein research.
Glycosylation is one of the most common post-translational modifications of proteins. It often determines the folding and trafficking of proteins and regulates almost all extracellular activities, including cell-cell communication and cell-matrix interactions. It has been shown that specific glycosylation changes are critical for disease progression and can be diagnostic for multiple disease types (e.g., cancer and inflammation). Thus, glycoproteins can serve as effective biomarkers for disease detection as well as targets for drug and vaccine development. Despite the importance of glycoproteins, the complex structure of carbohydrates and their derivatives in biological samples makes the overall analysis of glycoproteins extremely challenging.
Glycoprotein structure analysis in CD BioGlyco include but is not limited to the following technologies.
Glycan profiling of intact glycoprotein
The company uses ESI-TOF MS combined with RP HPLC or SEC, as well as MALDI MS and CE-MS for intact glycoprotein profiling.
Analysis of glycopeptides
The company provides ESI-MS, MALDI-MS, ETD, CID and CE-MS to analyze glycosylation sites and occupancy at the level of glycopeptides, and HPLC or HILIC are used to enrich glycopeptides.
Analysis of released glycans
Use MALDI-TOF MS to quickly analyze the released glycans and increase the ionization efficiency by glycan hypermethylation. Chromatographic methods (HILIC, RP HPLC, AE-HPLC or HPAEC-PAD) can also be used to separate labels Glycan.
Analysis of monosaccharides
HPAEC-PAD and RP HPLC are used to analyze monosaccharides.
“We provide comprehensive glycoprotein structure analysis services to help with customers' in-depth study of the heterogeneity and function of glycoproteins. Our professional research team can provide customers with different types of analysis data according to needs.” Said one of the representative speakers from CD BioGlyco.
Connect https://www.bioglyco.com/glycoprotein-structure-analysis.html to get more detailed information about the Glycoprotein Structure Analysis Services provided by CD BioGlyco.