Week 14 delivered some strong results with our NFL game picks and predictions against the spread. That doesn't mean much, however, unle s we follow with another fine slate in Week 15.The bye weeks have concluded as the final month of the 2021 regular season kicks off. The marathon is even longer this season with a Week 18 in play before getting into the playoffs toward Super Bowl 56.With every team back in action and some more ma sive and tiny spreads to navigate, here's Sporting News' latest fearle s forecast of thepigskin prognostications:(Game odds reflect opening odds for Week 15, courtesy of ) NFL POWER RANKINGS: NFL picks against the spread for Week 15Game of the Week: Packers (-5.5, 43.5 o/u) at RavensSunday 4:25p.m. ET, FoxThe Packers get a break here against a depleted pa s defense for Aaron Rodgers to attack and Aaron Jones can also have good versatile succe s out of the backfield. The Ravens like to blitz, but know they will be cooked trying that.vs. Rodgers and creating a lot of favorable one-on-ones. Baltimore's offense may not San Diego Padres Jersey have Lamar Jackson on the other side to combat an active Green Bay defense. Tyler Huntley can make the Ravens competitive again, but the defense is becoming a bigger problem than offense.Pick: Packers win 27-20 and cover the spread.Game of Midweek: Chiefs (-3, 50.5 o/u) at ChargersThursday 8:20 p.m.ET, Fox, NFL Network and Amazon Prime VideoThe Chiefs lost a 30-24 home game to the Chargers in Week 3, so this is the last game they need against the team one game behind to help secure another AFC West title. Justin Herbert has been on fire with Los Angeles' downfield pa sing game, but their rushing attack might be without dynamo Austin Ekeler on a short week. Herbert will play well again, but Patrick Mahomes has been money on the road and will outduelhim, with help from the better all-around defense and more traditional rushing succe s.Pick: Chiefs win 30-27 but fail to cover the spread.Result: Chiefs win 34-28 and cover the spread.Lock of the Week: 49ers (-8.5, 46 o/u) over FalconsSunday 4:05 p.m. ET, CBSThe 49ers are grooving offensively with Jimmy Garoppolo feeling it with dynamic triplets George Kittle, Deebo Samuel and Brandon Aiyuk. The Falcons cannot cover any of them in any way. The 49ers' run defense also can contain Cordarrelle Patterson and Mike Davis, Hunter Renfroe Jersey and get a break with their pa s rush being able to get after Matt Ryan while their secondary doesn't need to worry about more than two receivers.Pick: 49ers win 34-17 and cover the spread. Upset of the Week: Texans over Jaguars (-3, 41 o/u)Sunday 1 p.m. ET, CBS The Texans took down the Jaguars in Week 1 and will complete a season sweep on the road. Something must give here given the nature of anemic offenses and often porous defenses. Houston seems to be playing more inspired with Davis Mills and David Culley, while the Jaguars are going through the motions with Trevor Lawrence and the rest of his teammates after the rocky tenure ofUrban Meyer ended Thursday.Pick:Texans win 17-13.Patriots at Colts (-2, 45.5 o/u)Saturday8:15p.m. ET, NFL NetworkThe Patriots have a tricky matchup after a bye, given the Colts are hosting the game after their bye. Frank Reich does well in these situations, counteracting what Bill Belichick's team tends to do. The Colts will throw off the Patriots with their run-heavy attack with Jonathan Taylor, avoiding their strength in pa s defense. They also can win up front to contain Mac Jones' help. Indianapolis makes a mild statement in pushing for its own playoff return.Pick: Colts win 23-20 and cover the spread. Panthers at Bills (-10.5, 43.5 o/u) Sunday 1 p.m. ET, Fox The Bills should be coming home angry and emotional and ready to smash an NFC opponent. Why not the team after whichthey Luis Perdomo Jersey modeled their succe s?Josh Allen will play through his toe injury to destroy a wilting Panthers' defense, while Cam Newton/P.J. Walker face the wrath of Sean McDermott and Leslie Frazier's defense on every level.Pick: Bills win 34-17 and cover the spread.Jets at Dolphins (-8.5, 43 o/u)Sunday 1p.m. ET, CBSTua Tagovailoa and the Dolphins' pa sing game will come out with more confidence after the bye but their inconsistency in running the ball to go after the Jets' biggest defensive weakne s will keep the visitors hanging around in a division rivalry game. Look for Zach Wilson to respond well against the Dolphins' blitzes once or twice late to keep this game at a touchdown margin.Pick: Dolphins win 20-13 but fail to cover the spread. Cowboys (-10.5, 44.5 o/u) at GiantsSunday 1p.m. ET, Fox The Cowboys' offense is in a funk because of no reliable running game, shaky line play and Dak Prescott pre sing try to do too much and force things that aren't there to his explosive wide receivers. This screams get-well game for everything Dallas wants to do to move the ball with Kellen Moore. New York's shaky QB situation with nothing beyond Saquon Barkley leads to another rout.Pick: Cowboys win 30-13 and cover the spread.Titans (-2, 41.5 o/u) at Steelers Sunday 1 p.m.ET, CBSThe Titans will love this game because they can get physical for former Steelers linebacker Franchy Cordero Jersey Mike Vrabel and beat their hosts with their ideal style of play. Tenne see is still a strong running team when needed without Derrick Henry and Pittsburgh's run defense is a ultimate me s. The Titans are playing with more defensive confidence and will rattle Ben Roethlisberger enough as he tries to exploit their secondary.Pick: Titans win 20-17 and cover the spread.Cardinals (-14, 47 o/u) at LionsSunday 1p.m. ET, Fox The Cardinals won't be taking the Lions lightly given the way they have smashed some le ser teams this season with relentle s offensive diversity and swarming defense. The Lions' viable offensive options are dwindling at the wrong time around Jared Goff. Dan Campbell's team got Johnny Manziel Jersey its one home win out of the way. Detroit won't stand in the way Arizona steamrolling more toward the NFC's top playoff seed.Pick: Cardinals win 38-17and cover the spread. Bengals at Broncos (-1, 43.5 o/u)Sunday 4:05p.m. ET, CBSThe Bengals draw a tough road a signment as they try to rebound from the heartbreaking overtime home lo s to the NFC's 49ers. The Broncos have the same record, but their resume is le s impre sive overall. Cincinnati will trust fully in Joe Burrow to let it loose from the get-go, while Denver will try to get away with pa s-light game plan with Melvin Gordon and Javonte Williams hiding Teddy Bridgewater. It won't work with Burrow outplaying him grittily well in a key road spot.Pick: Bengals win 24-20.Saints at Buccaneers