Vidalista Black 80, which contains tadalafil, is a medication primarily used to treat erectile dysfunction. When it comes to combining it with antacids, there are no direct contraindications. However, antacids containing aluminum or magnesium can alter the absorption of tadalafil, potentially reducing its effectiveness. Vidalista Black 80 mg interaction can occur because antacids may change the pH level in your stomach, affecting how well the medication is absorbed. If you need to take an antacid, it's best to do so a few hours apart from Vidalista Black 80 to minimize any potential interaction. Always consult with your doctor or pharmacist before combining medications to ensure safety and efficacy.