Zhewitra, which contains the active ingredient vardenafil, is a medication commonly prescribed for erectile dysfunction. Combining it with caffeine, found in coffee, tea, energy drinks, and certain supplements, may raise some concerns. While caffeine itself does not directly interact with vardenafil, both substances can affect the cardiovascular system. Zhewitra can lower blood pressure by dilating blood vessels, while caffeine acts as a stimulant that may temporarily raise heart rate and blood pressure. In sensitive individuals, this combination might lead to palpitations, dizziness, or mild discomfort. Moderate caffeine intake is generally considered safe with Zhewitra, but excessive consumption should be avoided. If you have heart problems, high blood pressure, or anxiety issues, consult your doctor before combining Zhewitra with high amounts of caffeine.