Silditop 100, which contains 100 mg of sildenafil citrate, typically remains active in the body for about 4 to 6 hours after intake. The duration can vary slightly based on individual factors such as age, metabolism, overall health, and whether the drug was taken on an empty stomach. Silditop 100 mg works by increasing blood flow to the penis, allowing for an erection when sexually stimulated. While its peak effects occur about 30 to 60 minutes after ingestion, trace amounts of the drug may stay in the bloodstream for up to 24 hours. Consuming fatty meals, alcohol, or certain medications can reduce its effectiveness and duration.