Several physical factors can reduce the effectiveness of Cenforce 120 mg (sildenafil citrate) in treating erectile dysfunction (ED). While Cenforce works by improving blood flow to the penis during sexual stimulation, certain physiological and lifestyle conditions can interfere with its action.

1. Cardiovascular issues
Conditions like high blood pressure, atherosclerosis, or poor circulation can limit blood flow to the penis, making it harder for Cenforce to produce an erection, even at higher doses.

2. Diabetes
Men with diabetes may experience nerve damage (neuropathy) or blood vessel issues, which can reduce responsiveness to sildenafil.

3. Obesity
Excess body weight can affect hormone levels, reduce libido, and impair circulation, all of which can diminish Cenforce’s effectiveness.

4. Hormonal imbalances
Low testosterone levels or thyroid disorders can lower sexual desire and blunt the medication’s impact.

5. Smoking and alcohol
Smoking damages blood vessels, and excessive alcohol can depress the nervous system and reduce the body’s responsiveness to sexual stimulation, reducing the drug’s effectiveness.

6. Stress and fatigue
High stress, anxiety, or extreme fatigue can interfere with sexual arousal, limiting the response to Cenforce.

While Cenforce 120 mg is a potent option for ED, physical factors such as cardiovascular disease, diabetes, obesity, hormonal imbalances, smoking, alcohol use, and stress can reduce its effectiveness. Addressing these factors alongside medication often improves results.