YANGON Mets Jacob deGrom Jersey , June 4 (Xinhua) -- Myanmar has formed a 22-member soccer squad for friendly matches against selected Singaporean team and U-23 Vietnamese team, official media reported Tuesday.

The Myanmar head coach Park Sung-Hwa chose 22 players out of 30, who had received at training session in Taunggyi since May 21, based on their skills, fighting spirit, efforts and stamina Mets Gary Carter Jersey , in order to play friendly matches against Singapore and Vietnam respectively, said the New Light of Myanmar.

The U-23 team formed with 22 players has planned to leave for Vietnam on June 7 to play a friendly away match against Vietnamese U-23 team on June 11.

In Vietnam, the U-23 team will face two friendly matches of which one will be held at Dong Nai football stadium on June 9 against Dong Nai FC, a leading V-league club, while another will be at central football stadium in Ho Chi Minh on June 11.

Head coach Park said that footballers he picked were in the best position in Taunggyi training session and substitutions may be made in accord with their performance and stamina after league matches.

Luciano Berruti, who has joined 20 times of the total 21 editions Mets Dwight Gooden Jersey , rides a vintage bicycle during the "Eroica" cycling event for old bikes in Montalcino, Italy, on May 7, 2017. Cyclists from all over the world, wearing vintage cycling jerseys, riding vintage bicycles built in 1987 or earlier Mets David Wright Jersey , took part in the "Eroica" (heroic) cycling event here on Sunday. (XinhuaJin Yu)

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SAN FRANCISCO, June 11 (Xinhua) -- Researchers at the University of California, San Francisco, have drawn a link between distinctive genetic abnormalities in some neurodegenerative diseases and the formation of "RNA foci Mets Darryl Strawberry Jersey ," abnormal clusters of ribonucleic acid (RNA) molecules that accumulate in the cell nucleus.

The presence of RNA foci is a prominent feature of a group of deadly inherited neurodegenerative diseases, including Huntington's disease, certain forms of amyotrophic lateral sclerosis (ALS), and frontotemporal dementia.

While many researchers believe that these clusters are toxic to nerve cells, it has not been clear how or why they form.

Published online recently in the journal Nature, the new study focused on a group of disorders known as "repeat expansion" diseases. In these conditions Mets Asdrubal Cabrera Jersey , short strings of the deoxyribonucleic acid (DNA) "letters" known as nucleotides are abnormally repeated several times.

Over the course of an individual's life, or across generations, the number of such repeats can expand, which may increase disease susceptibility and severity within families.

Another suspect is messenger RNA, which is copied from the DNA and used by the cell to guide protein production.

Ronald Vale, professor in the UCSF's Department of Cellular and Molecular Pharmacology Mets Adrian Gonzalez Jersey , who led the new research, and UCSF postdoctoral fellow Ankur Jain, who performed the new experiments, found that each nucleotide repeat in RNA behaves like a small piece of molecular Velcro, or fastener, that can stick to repeats on other RNA strands.

"When you have lots of tandem pieces of Velcro Zack Wheeler Jersey , that allows one RNA strand to stick to multiple other strands with similar repeats," Vale said. "What you then get is many RNAs binding to one another to form a tangled gel."

Jain and Vale demonstrated this phenomenon in purified RNA in a test tube as well as when they artificially induced production of these disease-causing RNAs in cells in a dish.

"You start that process of making the RNA in cells and then can watch the gels forming in the nucleus in a time-lapse movie," Vale was quoted as saying in a news release.

And the two researchers found that about 30 nucleotide repeats were needed to trigger formation of RNA gels, similar to the number of repeats associated with the emergence of disease symptoms.

RNA gels did not form when Jain tested random nucleotide sequences that did not have disease-related repeating patterns.

In addition, while previous research indicated that RNA somehow combined with proteins to form foci, the new research suggests these clusters can arise from RNA alone.

"We have contributed a new hypothesis of how RNA foci form in these disorders Yoenis Cespedes Jersey ," said Vale. "Protein aggregation is a well-accepted cause of many neurodegenerative diseases, including Alzheimer's and ALS, but our work suggests that aggregation of RNA, by itself, might also be a culprit in neurodegeneration."

"Now we want to tackle new therapeutics by focusing on strategies that act on RNA and that could dissolve these potentially pathological structures," he said.

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