These may work by nourishing the nerve cells in the brain which are mostly made of DHE fatty acids. Depressed people have low DHE levels so the fish oil will raise these as well as lowering the risk of heart attacks, strokes and help build better bones. It is important to take vitamin C and E and other natural anti oxidants with these as they can produce free radicals if you take too much of them. Goji Juice is one of the best antioxidants. Also fish oils can sometimes interfere with anti-clotting medications.